IRF2BPL and synovitis: Significant reductions in the examined manifestations of DMM‐induced OA were observed in DMM + AAV‐sh‐Irf2bpl + ICG‐001 group compared with DMM + AAV‐sh‐Irf2bpl + vehicle group, including cartilage erosion, synovitis, SBP thickness and pain, but not osteophyte maturation (Figure 6E,G and Figure S6E), indicating that IA injection of ICG‐001 for 7 weeks significantly abolished the detrimental effects of AAV‐sh‐Irf2bpl on the progression of DMM‐induced OA, which was consistent with a previous report to a certain extent.47