In this work we found that, the cluster of EMT specially enriched in MYC-TARGET_V1 pathway, and representative gene clusters such as AP3S1, BUB3, EIFD3, LDHA, NMP1, PSMD14, SERBP1, SSBP1, UBE2L3, LOX, SERPINE1, TGFBI, and CD44 that affected the overall survival of PAAD. Here, TGFBI is linked to pancreatic adenocarcinoma.