To test if alterations in BDNF-dependent p-GR affect the onset and/or progression of AD-like neuropathology and cognitive decline, we crossed mice carrying a knockin allele lacking the conserved BDNF-responding phosphorylation sites orthologous to S134 and S267 in GR (Nr3c1 gene) that we previously described [2] with mice expressing the AD variants APPswe and PS1dE9 in the well-established line APP/PS1 [45]. Here, APP is linked to Mental deterioration.