FKBP5 and Alzheimer disease: Chaperones of GR (e.g. FK506 binding protein 5 (FKBP5) and heat-shock protein 90 (HSP90), were also found to have significantly reduced expression levels in AD compared to controls (FKBP5, − 34%, P = 0.002 and HSP90, − 51%, P < 0.0001, Additional file 1: Fig. S3).