In addition, recent studies have found that Tanshinone IIA, an extract derived from Salvia miltiorrhiza, can significantly inhibit SSc-induced skin and lung fibrosis caused by collagen deposition, reverse the bleomycin-induced EndoMT by inhibiting the Akt/mTOR/p70S6K pathway in vivo and in vitro, and alleviate SSc-induced vessels damage [6]. This evidence concerns the gene AKT1 and systemic sclerosis.