More importantly, Wenyang Huazhuo Tongluo Formula and KC7F2 significantly reduced the concentrations of vWF, SELE, ICAM-1 and VCAM-1 in serum (Fig. 2B-E), suggesting that Wenyang Huazhuo Tongluo Formula and KC7F2 can protect vascular endothelial cells and alleviate vessel damage in SSc. Here, ICAM1 is linked to systemic sclerosis.