In this study,we demonstrated that Wenyang Huazhuo Tongluo Formula can significantly reduce the concentrations of vWF, SELE, ICAM-1 and VCAM-1 in serum, suggesting that Wenyang Huazhuo Tongluo Formula can protect vascular endothelial cells and alleviate SSc-induced structural abnormalities. This evidence concerns the gene SELE and systemic sclerosis.