Also, the results of the KEGG pathway analysis showed that the 6 genes were significantly related to the cytosolic DNA-sensing pathway, the intestinal immune network for IgA production, tyrosine metabolism, phenylalanine metabolism, pertussis, graft-versus-host disease, viral myocarditis, legionellosis, autoimmune thyroid disease, malaria, type I diabetes mellitus, allograft rejection, African trypanosomiasis and antifolate resistance (Fig. 6D, Additional file 5). This evidence concerns the gene CD79A and graft versus host disease.