CD68 and adenoma: Given that platelet-derived poly P drives the release of NETs from neutrophils, et al. used biopsies of adenomas, hyperplastic polyps, IBD and healthy colon tissue were as a control study and found that in CRC, CD68 + mast cells expressing Poly P are one of the factors that stimulate the release of NETs from neutrophils, and mast cells with detectable CD68 + poly P expression could represent a potential prognostic marker for colorectal adenoma and/or carcinoma [129].