TNF and malignant colon neoplasm: A in vitro study analyzing the NETs-related proteins in colon tissues from patients with UC, CD and colon cancer demonstrated that PAD4, MPO, NE and citrullination histone H3 were highly expressed in pathological tissues of UC compared to CD, that UC-associated neutrophils yielded more NETs following TNF-α stimulation, and that those proteins expression was declined upon administration of anti-TNF-α therapy [115].