PADI4 and Sepsis: In an animal model of bacterial sepsis, DNase administration reduced organ damage and raised survival rates [35], and yet, DNase is administered prophylactically, which is impractical to patient care, and to further test this conclusion, the use of PAD4-/- mice to prevent the forming of NETs has shown to be protective against LPS-induced endotoxaemia, which indicates that NETs do exacerbate damage in sepsis [75].