RCC associated with Xp11.2 translocations/TFE3 gene fusions is the main pathological type and is characterized by chromosomal translocations involving the TFE3 gene on Xp11.2217–219 or the TFEB gene on 6p21.The most characteristic pathological manifestation is a papillary structure composed of clear cells, which is rarely seen in adult patients and is often associated with nest-shaped structures composed of tumor cells containing eosinophilic granules. This evidence concerns the gene TFE3 and neoplasm.