Binary logistic regression analysis suggested a significant association between the LRP5 rs556442 GG genotype and the risk of NAFLD in CHD patients (OR = 2.857, 95% CI: 1.196–6.824, P = 0.018), and this association remained significant after adjustment for age, sex, and BMI (OR = 3.252, 95% CI: 1.306–8.102, P = 0.011; Table 3). This evidence concerns the gene LRP5 and coronary artery disorder.