In the CHD group, the genotype distribution of LRP5 rs556442 was significantly different from that in the NAFLD + CHD group (P < 0.05), but the difference of allele frequency distribution of LRP5 rs556442 was not significant between CHD and NAFLD + CHD groups (P > 0.05). This evidence concerns the gene LRP5 and metabolic dysfunction-associated steatotic liver disease.