MAPK8 and infection: In addition to the role of DAF-16 during infections of cryptococci, we further determined DAF-16 mediators that also regulate the lifespan of C. elegans, including stress resistance by c-Jun N-terminal kinase (JNK) [46], calorie restriction by protein deacetylase (SIR) [47], superoxide dismutase (SOD), and osmotic stress resistant (OSR) [46].