APPL1 and Alzheimer disease: For example, we found that several of the genes with the highest log-fold variation in expression in the synganglion have vertebrates homologues which have been extensively studied for their association with Alzheimer’s Disease: this is the case for the APP-like peptide (APPL) and of tau protein [28], as well as a homolog of TIA-1, a gene associated with the development of tau protein [29].