MPO and Splenomegaly: Previous studies reported features predominantly seen in IE as compared to AAV, namely, extracardiac manifestations limited to skin and kidneys, splenomegaly, hypocomplementemia, dual ANCA positivity (specifically high PR3/low MPO), increased circulating immune complexes and/or immune complex deposition in histological specimen, other positive auto-antibodies, cryoglobulins, and positive blood cultures [45, 76].