To further exclude systemic effects on BP by hypercortisolemia and understand the role of GR in combination with renal ion transporters in BP regulation, the implication of renal tubular GR was further analysed in mice lacking GR either along the nephron (Nr3c1Pax8/LC1 [8]) or only in the distal nephron [22]. This evidence concerns the gene NR3C1 and adrenal gland hyperfunction.