TLR4 and cancer: Noteworthy, among the two species much more abundant in WN than in WT, Alistipes obesi is the only motile species within the genus Alistipes, while Alistipes shahii has a clearly defined pro-inflammatory activity by TLR4-priming/TNF production that may increase local inflammation but may also lead to beneficial immunomodulation in cancer treatment [27, 28].