The first subtype is MPAL with ZNF384 rearrangement, which commonly has a B/myeloid immunophenotype and is identified in ~50% of pediatric B/myeloid MPAL with fusion partners including TCF3, EP300, TAF15, and CREBBP. ZNF384-rearranged B/myeloid MPAL and B-ALL have similar transcriptional profile, suggesting a biological continuum [79]. Here, EP300 is linked to mixed phenotype acute leukemia.