New conditions included are monoclonal gammopathy of renal significance (MGRS), cold agglutinin disease (CAD), as well as TEMPI syndrome (a provisional entity in WHO-HAEM4R, characterized by telangiectasias, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting) and AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma). Here, EPO is linked to cold agglutinin disease.