TP53 and B-cell chronic lymphocytic leukemia: In addition to del(11q), del(13q), del(17p), and trisomy 12 assessment, TP53 mutational analysis, immunoglobulin gene heavy chain variable (IGHV) region somatic hypermutation (SHM) analysis and B-cell receptor stereotype subset analysis (subset #2 configuration) are all essential for full prognostic evaluation of CLL/SLL [39–41].