In one study evaluating anti-MAA antibody concentrations across all isotypes (IgA, IgG, IgM) in RA patients compared to both healthy volunteers and three diseased control groups (osteoarthritis, systemic lupus erythematous, spondyloarthropathy), only the IgA isotype was found to be significantly higher28. Here, CD40LG is linked to rheumatoid arthritis.