GRM3 and Alzheimer disease: As layer III dlPFC is a focus of pathology in both schizophrenia [44] and AD [45], and dlPFC is also a focus of cognitive deficits in multiple sclerosis [46], this mechanism has particular clinical relevance, suggesting that elevated GCPII in dlPFC may contribute to dlPFC dysfunction in inflammatory disorders by eroding beneficial mGluR3 signaling.