As layer III dlPFC is a focus of pathology in both schizophrenia [44] and AD [45], and dlPFC is also a focus of cognitive deficits in multiple sclerosis [46], this mechanism has particular clinical relevance, suggesting that elevated GCPII in dlPFC may contribute to dlPFC dysfunction in inflammatory disorders by eroding beneficial mGluR3 signaling. This evidence concerns the gene GRM3 and schizophrenia.