In conclusion, while previous studies have illustrated that R. rosea has anti-inflammatory and gut microbiome-modulating properties and can extend lifespan in several animal models, the present study demonstrates that short-term exposure to R. rosea has beneficial effects on glucose homeostasis in the Leptin receptor knockout (db/db) mouse model of severe T2D, and suggests a possible mechanism of action. The gene discussed is LEPR; the disease is type 2 diabetes mellitus.