The cancer genes contained in the census included CDKN1A, LARP4B and SLC45A3. Previous studies showed that LARP4B inhibited the migration and invasion of prostate cancer cells32, SLC45A3 downregulation was significantly associated with shorter PSA-free survival times, and the expression of SLC45A3 protein was downregulated through SLC45A3-ERG fusion51. This evidence concerns the gene LARP4B and Familial prostate cancer.