In addition, we found that the level of DNA damage was obviously increased after ARIH2 knockdown and that ARIH2-knockdown GC cells showed a higher degree of apoptosis after the combined treatment with 5-fluorouracil, indicating that ARIH2 is involved in DNA damage and that ARIH2 regulates chemosensitivity of GC cells. Here, ARIH2 is linked to gastric cancer.