In addition, we have used two different animal models of PAH: (A) Il6tg mice expressing Il6 in pneumocytes that develop severe angioproliferative PAH in hypoxic conditions and (B) Monocrotaline (MCT) exposure in rats exhibiting endothelial dysfunction followed by robust angioproliferative remodeling in small pulmonary arterioles. The gene discussed is IL6; the disease is endothelial dysfunction.