CD4 and neoplasm: To assess the role of conventional DC (cDC1) in BCG-induced immune responses, we used Batf3-/- mice, lacking cross-presenting cDC1.14 Tumor growth control by BCG lysate was abrogated in Batf3-/- mice (figure 2J) and there was no BCG-induced increase in the frequencies of CD45+ immune cells, CD8+ and CD4+ T cells, NKT and NK cells (figure 2K–O).