CTSS and cutaneous melanoma: Furthermore, CTSS expression positively correlated with the M1 MΦ and mature DC signature in the skin cutaneous melanoma (SKCM) cohort from The Cancer Genome Atlas (TCGA) consortium (online supplemental figures S10A, B).37 Stratification of the patients in CTSShigh and CTSSlow (split by quartile), revealed a significantly increased expression of the M1 MΦ and mature DC signature in CTSShigh patients (online supplemental figures S10C, D).