The levels of both proteins were significantly elevated in PD patients with mean fold changes of 1.22 (OMD) and 1.12 (CD44) in the HBS and 1.17 (OMD) and 1.07 (CD44) in the LCC cohort (Figures 3B–3E). This evidence concerns the gene CD44 and leukoencephalopathy with calcifications and cysts.