The persisting immune response hypothesis has been fueled by the finding of immunogenic viral particles in multiple tissues, including but not limited to the respiratory tract, kidneys, brain, and gastrointestinal and cardiac systems months after infection12 and elevated levels of highly activated CD38+HLA-DR+ myeloid cells and CD14+CD16+ monocytes, which are also reported to contain persisting S1 proteins in PASC patients,83 as well as plasmacytoid dendritic cells (pDCs) and several interferons in the blood of PASC patients.81 The gene discussed is CD38; the disease is long COVID-19.