PDE5A and esophageal squamous cell carcinoma: To assess the suitability of PDE5 as a target in EAC, we determined the expression of PDE5A in EAC relative to normal tissue, esophageal squamous cell carcinoma (ESCC), and the EAC-related pre-cursor condition Barrett’s esophagus (BE) in publicly available gene expression datasets with matching tissue samples.