Moreover, further analysis of the A375 tumors treated with A922500 revealed increased SESN2, SOD1, and SOD2 expression (Figure S6A), concomitant with increased lipid peroxidation, confirming that our A922500 administration had been effective in inducing ROS and NRF2 signaling in tumor cells in vivo. Here, SESN2 is linked to neoplasm.