SOD1 and melanoma: Indeed, inhibition of DGAT1 in melanoma cell lines led to increased SOD1 and -2 as well as SESTRIN2 (SESN2) (Figure S6B), a NRF2 activator induced upon mitochondrial respiratory malfunction (Bae et al., 2013; Garaeva et al., 2016), in agreement with our earlier MS-based whole-proteome and quantitative PCR analyses demonstrating activation of NRF2 signaling following DGAT1 inhibition (Figures 5A and 5B).