In addition, we found that epigenetic modifiers, such as Entinostat and Vorinostat, increase γδ T cell functions through upregulation of MICA/MICB and downregulation of PD‐L1 in CAFs and melanoma cells; while downregulation of PD‐1, upregulation of CXCR3 and CD107a expression and IFN‐γ production in γδ T cells. This evidence concerns the gene CD274 and melanoma.