To investigate the mechanism by which CKS1i induces divergent responses between healthy and malignant hematopoietic cells, we carried out proteomic analysis of CKS1Bhigh AML cell lines, which demonstrate direct correlation between CKS1B expression and CKS1i response, phenocopying primary patient AML (Supp. Here, CKS1B is linked to acute myeloid leukemia.