We previously reported a regulatory axis between the cyclin-dependent kinase subunits Cks1 and Cks2, and the mixed lineage leukemia 1 protein (Mll1), a key protein hijacked during neoplastic transformation of the hematopoietic system(8), and important for regulation of normal and cancer stem cells from multiple different tissues(9, 10). This evidence concerns the gene CKS1B and cancer.