SREBF1 and hepatocellular carcinoma: We observed a similar effect with regard to the increased abundance of PUFAs in HCC; although expression of the master transcription factor SREBF1 was up-regulated in HCC tumors compared to adjacent normal thyroid (log2 fold change = 1.10, q = 0.041), expression of SCD (which introduces double bonds into stearoyl–coenzyme A (CoA) and palmitoyl-CoA and is believed to be the rate-limiting step in MUFA biosynthesis) was not significantly overexpressed in HCC tumors (log2 fold change = 1.87, q = 0.18).