In contrast, HCC tumors had comparatively lower infiltration of CD8+ cells (CD8.T.cells, P = 3.53 × 10−2, Wilcoxon rank sum test), T helper 17 cells (Th17.cells, P = 2.52 × 10−2, Wilcoxon rank sum test), T helper cells (T.helper.cells, P = 2.12 × 10−2, Wilcoxon rank sum test), and natural killer (NK) cells (NK.cells, P = 4.16 × 10−2, Wilcoxon rank sum test) (Fig. 3C and table S3A). This evidence concerns the gene CD8A and hepatocellular carcinoma.