Figure 8I illustrates a strong negative correlation between static compliance and hydroxyproline content. Besides, the elastance was positively related to the hydroxyproline content (Fig. 8J). The correlations between hydroxyproline content and other pulmonary function parameters were also shown in fig. S18. Together, we demonstrate that the therapeutic inhibition of IL-11 using the inhalable siIL11@PPGC NPs holds great promise in resolving pulmonary fibrosis and restoring healthy lung function. This evidence concerns the gene IL11 and pulmonary fibrosis.