miR-486-5p protects against cardiac ischemic injury and targets PTEN, suppressing cardiomyocyte apoptosis in cardiac IRI [17, 81], improves cardiac function and promotes angiogenesis after myocardial infarction associated with targeting Mmp-19 in cardiac fibroblasts [65], and reduces IgE-mediated cardiac fibrosis by targeting Smad1 [19]. This evidence concerns the gene SMAD1 and myocardial infarction.