It was found that the levels of p-LATS2 and p-YAP were downregulated in septic mice and LPS-induced intestinal cells, indicating an inactivation of Hippo signaling pathway in sepsis, whereas FK886 had the ability to partly restore the activity of Hippo signaling, suggesting that FK886 might stimulate the activation of Hippo signaling, followed by YAP phosphorylation and degradation, leading to the attenuation of intestinal inflammation and cell apoptosis. The gene discussed is LATS2; the disease is Sepsis.