NAMPT and obesity due to melanocortin 4 receptor deficiency: To the best of our knowledge, the direct association between Visfatin and Hippo/YAP pathway in sepsis-related intestinal injury has not been reported yet; however, Visfatin was evidenced to serve a role linked to Sirt1/YAP pathway in obesity-associated gastric cancer, which partly indicates the connection between Visfatin and Hippo/YAP signaling [22].