However, despite a high frequency of Apolipoprotein E allele amongst those of African ancestry (Zekraoui et al., 1997), it does not appear to be as important a risk gene for Alzheimer’s disease development in this population (Farrer et al., 1997; Hendrie et al., 2014). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.