APP and Alzheimer disease: Methodologically comparable 10x Genomics single-cell RNA-sequencing (RNA-seq) analyses have been performed for both granuloma macrophages from zebrafish infected with Mycobacterium marinum (Cronan et al., 2021), a widely studied fish model for M. tuberculous infection (Ramakrishnan, 2020), and microglia associated with dense-core Aβ plaques in the APP/PS1 mouse model of AD (Huang et al., 2021).