HEXB and lysosomal storage disease: Hexb−/− mice and other lysosomal storage disease models exhibit amyloid-related histopathology (Annunziata et al., 2013; Keilani et al., 2012), and it has recently been shown that Hexb+/− heterozygotes, when crossed into the amyloidogenic AppNL-G-F mouse (Saito et al., 2014), exhibit decreased Aβ deposition relative to AppNL-G-F alone (Whyte et al., 2022).