TREM2 and Alzheimer disease: Some features of microglial interaction with plaques in TAM-deficient APP/PS1 mice resemble those seen when mice lacking the microglial phagocytic receptor Trem2 (Ulland and Colonna, 2018; Wang et al., 2015) are crossed with amyloidogenic mouse AD models (Huang et al. [2021] and references therein).