According the study by Nauck and Meier, observed clinical improvement in obesepatients after bariatric surgery results in the consequence of the early passage offood in the gastrointestinal tract and in turn stimulates the mucosa by increasingthe production of enteral hormones, such as GLP-1 and GIP, which contribute to theimprovement of glycemic control and satiety at the hypothalamus level, and theseeffects are reflected in improved diabetic status and obesity .22 The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.