SLC11A2 and hypochromic anemia: Among the mutations identified in the SLC11A2 gene, which encodesthe DMT-1 protein, two were more associated with the clinical condition ofmicrocytic hypochromic anemia of a genetic cause, due to changes in proteinconformation: (1) The 1285G-C transversion (IVS12ds-1 GC), in exon 12/intron 12,which results in the replacement of glutamic acid by aspartate, by changing the GAGcodon to GAC, at position 399 (Glu399Asp; E399D)9; (2) the 1246C-T transition, in exon 13, by changing the CGC codon to TGC,at position 416, resulting in the replacement of arginine by cysteine (Arg416Cys;R416C).8