The discovery of other genes involved in iron deficiency, such as STEAP3/TSAP67 or TMPRSS612, or new mutations in already identified genes, such as the N491S and G212Vmutations, both in the SLC11A21 gene, suggests that these conditions may be more frequent than initiallyassumed and the clinical diagnosis of these conditions should be based on the firstset of hematological and serum iron evaluation, followed by genetic testing, asperformed in the present study. The gene discussed is STEAP3; the disease is nutritional disorder.