An increase in the inflammatory cytokines affectingthe microvascular vasomotor mechanisms, such as interleukin (IL)-1, IL-6, tumornecrosis factor-alpha, elevated C-reactive protein in blood, intercellular adhesionmolecule-1, and high homocysteine levels have been shown to confirm its role inendothelial dysfunction and atherosclerosis(23). The gene discussed is CRP; the disease is atherosclerosis.