This contrasts with a recent study reporting that tamoxifen-inducible, cardiomyocyte-specific knockout of both PKN1 or PKN2 (not either gene alone) in adult mice, reduced cardiac hypertrophy in models of pressure-overload, namely thoracic aortic constriction (TAC) or AngII [25]. The gene discussed is PKN2; the disease is cardiac hypertrophy.