In addition, it has been reported that HOXC10 promotes tumor angiogenesis and induces VEGFA expression in glioblastoma by binding to protein arginine methyltransferase-5.19 Our results revealed that miR-4739 overexpression decreased VEGFA expression in ESCC cells by downregulating HOXC10 expression, thus inhibiting tumor angiogenesis in vitro. The gene discussed is PRMT5; the disease is esophageal squamous cell carcinoma.