Up to now, the effect of insulin and KLF10 on osteoblasts proliferation and differentiation, expression of bone metabolism-related molecules and related signaling pathway molecules of AKT serine/threonine kinase 1 (AKT) and nuclear factor kappa B subunit 1 (NF-κB) level on dental implant osseointegration in patients with diabetes mellitus is still unclear. The gene discussed is INS; the disease is diabetes mellitus.