Indeed, the only reported effects of TROP2 deficiency on mouse or human development are light-induced corneal opacity and gelatinous drop-like corneal dystrophy, respectively, as well as an increased epidermal permeability identified in our current study (Fig. 4) (Nakatsukasa et al., 2010; Nagahara et al., 2020). Here, TACSTD2 is linked to corneal dystrophy.