We assessed the effects of NR+Caff in NPCs and astrocytes on the transcription of NRK1, NMNAT2, NAMPT, NAPRT, and CD38, CD157 (BST1), and SARM1, which have been implicated in aging, neurodegeneration, and AD (see Figure 1a, and summarized in [Covarrubias et al., 2021; Verdin, 2015]). This evidence concerns the gene BST1 and Alzheimer disease.