Consistently, the protein levels of PI3K (0.6863 ± 0.06622 vs. 0.4163 ± 0.05752, p = 0.0053, Fig. 8D and 8F) and phosphorylated AKT1 (0.3085 ± 0.06719 vs. 0.164 ± 0.03512, p = 0.0299, Fig. 8E and 8G) were also higher in lung tissues from PD150606-treated compared with vehicle bleomycin model of SSc wild-type mice. Here, AKT1 is linked to systemic sclerosis.