However, the levels of PI3K (0.72 ± 0.08 vs. 0.43 ± 0.06, p = 0.034, Fig. 8A and 8B) and phosphorylated AKT1 (0.98 ± 0.17 vs. 0.68 ± 0.03, p = 0.002, Fig. 8A and 8C) were relatively higher in bleomycin model of SSc Capns1-ko compared with bleomycin model of SSc wild-type lung tissues. Here, CAPNS1 is linked to systemic sclerosis.