In support of pro-inflammatory phenotype of M1 macrophages, bleomycin model of SSc mouse lungs displayed a significant increase in M1 macrophage-expressed cytokines including TNF-α, IL12 and IL23, which was not observed in bleomycin model of SSc Capns1-ko mice (Fig. 7). The gene discussed is CAPNS1; the disease is systemic sclerosis.