CAPNS1 and systemic sclerosis: Flow cytometry analysis revealed that the percentage of F4/80+MHC II+ M1 cells was significantly higher in bleomycin model of SSc compared with sham treated mice (13.83 ± 2.88 vs. 0.47 ± 0.32, p = 0.001, Fig. 6A), and this increase in percentage of F4/80+MHC II+ M1 cells was attenuated in bleomycin model of SSc Capns1-ko mice (13.83 ± 2.88 vs. 1.86 ± 0.83, p = 0.002, Fig. 6A).