Hsa_circ_0002130 was reported to be upregulated in PC cell-derived exosomes irradiated at a dose of 10 Gy and was predicted to have binding sites for miR-4482-3p, and nibrin (NBN), which is associated with PC prognosis, was identified as a possible downstream target of miR-4482-3p [56]. The gene discussed is NBN; the disease is pachyonychia congenita.