The mesenchymal stem cells release exosomal miR-644-5p, miR-144-5p to inhibit ovarian granulosa cell apoptosis through targeting p53 or Pten [47, 48], In the chemotherapy-induced rat POF model, the NGF/TRK pathway is involved in and contribute to the amelioration effect of mesenchymal stem cells on POF [49]. Here, PTEN is linked to premature menopause.