Because hyperandrogenism is frequently observed in women with PCOS, who are characterized by anovulation associated with abnormal gonadotropin secretion, which is reflected by abnormal GnRH pulse frequency, we speculated that an excess of androgens would have an effect on KNDy neurons, which govern the secretory patterns of GnRH. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.