Distribution patterns within platelets were imaged by STED microscopy for 6 different proteins, all reported to play a role in tumor-mediated protein storage and release in platelets [8, 19, 27–29, 36]: VAMP7 (v-SNARE), VAMP8 (v-SNARE), VEGF (pro-angiogenic), TSP1 (anti-angiogenic), STX11 (t-SNARE) and SNAP23 (t-SNARE). This evidence concerns the gene THBS1 and neoplasm.