CLU and Alzheimer disease: Both the SNP-level analysis and gene-level analysis converged on the same relevant risk loci, the same potential causal variants as well as the same risk genes, including previously discovered genes associated with LBD (SNCA [4q22.1], APOC1 [19q13.32]), and three potential novel genes CLU (8p21.1), MAPT (17q21.31), and FBXL19 (16p11.2).CLU, which encodes clusterin, a glycoprotein associated with AD, binds α-synuclein aggregated species and is present in Lewy bodies, intraneuronal aggregates mainly composed of fibrillary α-synuclein [61, 62].