CXCL12 and non-small cell lung carcinoma: Liao et al. [56] confirmed that CXCL12 stimulated CXCR4 expression and then increased soluble vascular cell adhesion molecule 1 (sVCAM1) secretion in NSCLC, which could recruit and arrest osteoclast progenitors to promote osteoclastogenesis in metastatic bone tissue.