IFIH1 and infection: Both melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) were necessary to activate interferon signaling in response to host cell infection by various viruses, including ebola virus (EBOV), influenza A virus, Middle East respiratory syndrome coronavirus, human T-cell leukemia virus 1, mouse hepatitis virus, measles virus, and herpes simplex virus 1 [13, 14].